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Description Application 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.[2] General description 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity.[1] It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. [1] Patrick Imesch et. al,Experimental and therapeutic medicine, 6(3), undefined (2013-10-19) [2] Uffe Koppelhus et. al,Antisense & nucleic acid drug development, 12(2), undefined (2002-6-21) [3] Matthias Kuhlmann et. al,Molecular therapy. Nucleic acids, 9, undefined (2017-12-17) |
